Obesity is an important co-morbidity with high blood pressure and mellitus diabetes. There are few medications for obesity treatment including orlistat and lorcaserin, which are recently approved. Serotonergic feature and anorexic activity of Lorcaserin powder. The treatment can cause severe side effects, particularly if taken on certain medicines that increase levels of serotonin or activate serotonin receptors. Serotonin syndrome. While the basic and first line of treatment strategy would still remain low calorie diet and physical activity increase. The new hope of Lorcaserin is that obesity treatment will be effective, but it is still a long way away with a lot more studies in obesity treatment.
The Effects Of Obesity
Obesity has grown into a pandemic in all strata of culture. Man has fought against this disease and without much success it was a long fight. The study demonstrated obesity affecting developed and developing countries, although the incidence was higher (35.2%) in developed nations compared with developing countries (19.6%) with a global 33% population. If this pattern persists, 3,3 billion people will be affected by this pattern in 2030. Obesity is an significant public health issue, particularly when it coexists with other conditions of comorbid age, such as hypertension and diabetes mellitus. Adipose itself is a single predisposing factor for multiple diseases and impacts individuals in society physically and emotionally.
The key preventive factor is the ingestion and improvement in physical exercise of the reduced calorie diet, which cannot be done for all because of a lack of inspiration. A relatively limited number of medications are available for obesity treatment; the last medication to be approved in 1999 by the Food and Drug Administration (FDA) was orlistat, and after 13 years the FDA approved a new prescription drug in June 2012. Finally, it has been accepted with more testing and more results. It also brings new hope to patients who are obese and who are particularly affected by other comorbid conditions, such as Hypertension, Diabetes mellitus and arthritis.
How Does Loracserin Powder Help
Lorcaserin powder is consumed quickly and delayed with fetty meals in the gastrointestinal tract. The maximum plasma concentration with a half-life of 11h is 1.5-2 hours. Both brain fluid and the central nervous system, it is uniformly distributed. 70 percent plasma protein is bound in the liver with lorcaserin sulfamate being the main metabolite and excreted primarily by urine (92 percent) and minimal facial excretion.
Medicines that impair the neurotransmission of serotonin should be used with caution, such as inhibitors of selected serotonin ruptures, serotonin norepinephine ruptures and monoamine oxidasis, which may contribute to serotonin syndrome. Serotonin syndrome is attributed to the rapid onset of symptoms such as elevated pressure in the blood, shivering and sweating in the body, caused by toxicity of the serotonin. Drugs like dextromethorphan, which are blocked by lorcaserin and which are metabolised by cytochrome P450 2D6, appear to increase blood pressures when given together
The approval for Lorcaserin powder is focused on three major clinical studies; behavioural therapy and overweight lorcaserin analysis, behavioural modification and lorcanic overweight and obesity analysis (BLOOM DM) from tadalafil manufacturer and non-randomized weight reduction trial for obesity and overweight adults of the BLOSSOM study in patients with type 2 diabetes.